association of microalbuminuria and estimated glomerular filtration rate with carotid intima-media thickness in patients with type 2 diabetes mellitus

conclusions our study shows a relationship between cimt and renal parameters, including egfr and albuminuria. this study confirms the importance of intensive examinations for early detection of atherosclerosis and treatment of risk factors. patients and methods this cross-sectional study was included 205 patients with type 2 diabetes mellitus (t2dm). we recorded clinical and biochemical data such as fbs, lipid profile, and urinary albumin. intima-media thickness of carotid arteries was measured in all patients by high frequency ultrasound. results in simple correlation coefficients analysis, cimt was significantly associated with total cholesterol (r = 0.197, p = 0.008), serum creatinine (r = 0.240, p = 0.001), and urinary albumin (r = 0.420, p = 0.000). also, cimt elevated significantly with the stage progression of chronic kidney disease (0.67 ± 0.15 mm in stage 1, 0.73 ± 0.22 mm in stage 2, and 0.82 ± 0.21 mm in stage 3) (p value = 0.024). in multivariate linear regression analysis, the duration of diabetes, weight, hdl, serum creatinine, urinary albumin, and estimated glomerular filtration rate (egfr) were independently associated with cimt (p value < 0.05 for all). background atherosclerosis is the main cause of cardiovascular diseases, and its risk enhances in type 2 diabetes mellitus. objectives this study aimed to evaluate carotid intima-media thickness (cimt) by carotid artery ultrasonography and assess its correlation with microalbuminuria and estimated glomerular filtration rate (egfr) in the patients with type 2 diabetes mellitus.